Synthetic insulation is bulkier, heavier, and less effective period. It is without a doubt an inferior insulation in every way, except if it gets wet, which I can't ever remember dunking my sleeping bag in the creek, which is always stuffed in a dry bag. As a matter of fact in the decade I've been backpacking (many more times per year than the avg packer) I've never gotten my sleeping bag wet once, ever. Don't swim with it and don't sleep in a creek and your bag won't get soaked.
Here is a video showing the HUGE difference between a high-end 20F synthetic bag and a high-end 20F down bag -----> COMPARISON
If properly cared for down lasts forever, synthetic doesn't. The only reason to ever have a synthetic over a down bag is cost. If you can't afford down, get some synthetic and get out in the woods anyway, but I promise you, once you experience down, there is nothing else.
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