Looking at the terrain, if we hike NOBO out of the hang we will have to hike the 16 mile flat stretch of the Cumberland Valley. I didn't think it was that bad but there is no camping or official water for that stretch so it will affect logistics for sure. 2 miles NOBO PGF state park is an excellent overlook with a hidden campsite that can accommodate many hangers. Just throwing out some ideas, I'm open for 5 mile days or 20. Doesn't matter to me.
SOBO (or NOBO if we pre- hike) is a lot more scenic (IMHO) and has better hang sites.
Keep the ideas coming though! We still have a while to plan. From the maps I have, it looks like we are pretty much stuck hiking on the AT if we go NOBO. SOBO would be through Michaux Forest which has tons of spur trails and probably great hang sites.