My mother never got bit by a mosquito in her life - they just didn't like her (she was also immune to poison ivy, oak, & sumac). On the other hand, if there's a mosquito within a 100-mile radius it will find me.
So yes, it's possible to go without a bugnet if you're more like my momma than me. No way a single application of deet would last me through the night.
Not only do mosquitoes love me but I also have sometimes severe reactions. I've accidentally rested my hand against the bugnet while sleeping, and woken up in the morning with multiple bites on my hand, with it swollen up like a boxer's glove.
On top of all that, I'm an involuntary scratcher. I don't even know I'm doing it, but I'll scratch at a mosquito bite till I'm bleeding.
The only natural way I've found to combat mosquitoes is to eat a ton of garlic. The mosquitoes don't seem to like that garlic stench (nor do most humans, unless you're French).